阿德福韦酯联合双歧三联活菌治疗乙肝肝硬化腹水的疗效评价

目的评价阿德福韦酯联合双歧三联活菌治疗乙肝肝硬化腹水的疗效。方法选择肝硬化腹水患者共91例，随机分为治疗组（阿德福韦酯10mg每日一次，双歧三联活菌2．0g每日三次）46例，对照A组（双歧三联活菌2．0g，每日三次）23例，对照B组（仅常规治疗）22例。三组患者均给予常规治疗（护肝、利尿、定期输白蛋白或者血浆对症支持等），分别于用药3个月和12个月后观察和评估患者肝功能改善、腹水消退及再发率情况。结果治疗组的肝功能改善、腹水消退明显优于对照A组和对照B组，差异有统计学意义（P〈0．05）；治疗组腹水再发生率为11．4％，与对照A组腹水再发生率（81．8％）和对照B组腹水再发生率（90．0％）相比，差异具有统计学意义（P〈0．05）。结论阿德福韦酯联合双歧三联活菌治疗肝硬化腹水有较好的疗效，值得临床借鉴。

The effect evaluation of adefovir dipivoxil associated with live combined Bifidobacterium and lactobacillus on patients with type B cirrhosis with ascites

Objective To evaluate the therapeutic effect of adefovir dipivoxil associated with live combined bifidobacterium and lactobacillus in the treatment of pateints with type B posthepatitic cirrhosis and ascites.Methods Ninety-one patients with type B hepatitis liver cirrhosis and ascites were collected,who were accepted conventional treatment after admission including protecting liver,diureses and regularly transfusion albumin or plasma etc.All the patients were randomly 1divided into treatment group(46 cases received adefovir dipivoxil 10 mg once a day and live combined bifidobacterium and lactobacillus tablet 2.0 g three times a day treatment),control A group(23 cases,received live combined bifidobacterium and lactobacillus tablet 2.0g three times a day treatment) and control B group(22 cases received conventional treatment only).Hepatic function and ascites were assessed after treatment for 3 months and 12 months respectively.Results The liver function improvement and ascites extinction were significantly better in treantent group than that in control A group and control B group,the difference had statistical significance(P < 0.05);The ascites recur rate was 11.4% in treatment group,which compared with that in control A group(81.8%)and control B group(90.0%) had statistics difference(P < 0.05).Conclusion The therapy of adefovir dipivoxil associated with live combined bifidobacterium and lactobacillus on pateints with type B posthepatitic cirrhosis and ascites has a good effect,which is worth of learning.