抑郁症自杀意念患者人格特质与蛋白激酶PKB1基因多态性的关联性

目的 探讨蛋白激酶PKB1基因多态性对中国汉族抑郁症自杀意念患者所测艾森克人格特质的影响.方法 收集2015年1月至2016年12月东莞市精神卫生中心与海南省精神卫生中心的100例中国汉族抑郁症自杀意念患者为研究对象,采用艾森克人格问卷(EPQ)测量其人格神经质(N)、内外向(E)、精神质(P)三个维度,计算各维度标准分(T).聚合酶链反应(PCR)检测PKB1基因的单核苷酸多态性(SNP).结果 本研究检测到PKBrs2494746基因型分布在总样本中均符合Hardy-Weinberg遗传平衡(P>0.05),具有群体代表性.年龄、性别在内外向(E)、神经质(N)、精神质(P)各人格维度分级间比较差异均无统计学意义(P>0.05),样本具有可比性.E(51.67±9.87)、N(36.18±4.69)、P(39.67±12.91)各人格均数在PKB1 rs2494746不同基因型及等位基因间比较差异无统计学意义(P>0.05).结论 PKB1rs2494746单位点与中国汉族抑郁症自杀意念患者所测人格可能无关联.

Correlation between personality traits and protein kinase PKB1 gene polymorphism in patients with depression and suicidal ideation

Objective To explore the effect of protein kinase B1 (PKB1) gene polymorphism on Eysenck per-sonality traits in Chinese Han patients with depression and suicidal ideation Methods A total of 100 Chinese Han pa-tients with depression and suicidal ideation in Dongguan Mental Health Center and Hainan Provincial Anning Hospital from January 2015 to December 2016 were selected as the research objects. Eysenck Personality Quesrionnaire (EPQ) was used to measure the three personality dimensions of neuroticism (N), introversion-extraversion (E) and psychoticism (P), and the standard scores of each dimension (T) were calculated. Single nucleotide polymorphism (SNP) of PKB1 genes were detected by polymerase chain reaction (PCR). Results The result showed that the distribution of PK-Brs2494746 genotypes in the total samples was consistent with Hardy-Weinberg equilibrium (P>0.05). There were no significant difference in distributions of mean age and gender between different personality dimensions (E, N, and P) (P>0.05). There was no significant difference between different genotypes and alleles of PKB1 rs2494746 in E (51.67 ± 9.87), N (36.18 ± 4.69), P (39.67 ± 12.91) (P>0.05). Conclusion No significant associations were found in PKB1 single gene and EPQ personality in Chinese Han patients with depression and suicide ideation.