DC-SIGN固有免疫调节机制的研究进展

树突状细胞(DC)是目前已知功能最强的抗原呈递细胞.它既可以激活初始免疫应答,又能够抑制免疫反应,这与其表达的多种模式识别受体有关,其中DC-SIGN是C型凝集素受体的主要成员,由于它在DC的细胞粘附、迁移、激活初始T细胞、引发免疫反应及参与病原体免疫逃逸等多个方面发挥免疫调节作用,已经成为近年来的研究热点,对其功能的研究可能会为某些疾病提供新的治疗方法,具有重要的临床意义.本文就DC-SIGN免疫调节机制的最新进展做一综述.

Advances in the study of regulation mechanisms of innate immunity of DC-SIGN

It is well known that dendritic cells are the most potent antigen presenting cells. They can activate primary immune response, but also downregulate immune response, which relates with a variety of pattern recognition receptors expressed by them. DC-SIGN (DC-specific ICAM-3-grabbing nonintegrin, CD209) is primary member of the C-type lectin receptors. In recent years, DC-SIGN has received great attention due to its important role in immunological regulation such as mediating cell adhesion, migration, activating primary T cells, triggering the immune response and im-mune escape of pathogens. The study of DC-SIGN can provide us with a new method in treating certain diseases and have important clinical significance. This article reviews the latest advances in DC-SIGN immunoregulatory mechanisms.