西地那非治疗顽固性高血压患者疗效观察

目的 观察枸橼酸西地那非对顽固性高血压患者的临床疗效.方法 选取2013年1月至2016年10月海南医学院附属第二医院顽固性高血压住院患者52例为观察对象,采用随机、单盲、安慰剂对照的方法分为西地那非组和安慰剂组各26例,所有患者治疗8周,通过治疗前、后24 h动态血压变化评价西地那非对于顽固性高血压的疗效.结果 经过8周治疗,西地那非组患者24 h平均动脉压的降幅明显优于安慰剂组[收缩压(SBP)(-8.8±1.4)mmHg vs(1.3±1.2)mmHg;舒张压(DBP)(-5.3±3.3)mmHg vs(1.8±1.1)mmHg;平均动脉压(MBP)(-7.9±3.6)mmHg vs(0.8±0.9)mmHg],血压降幅在白昼更加明显[SBP(-6.0±4.7)mmHg vs(4.4±1.5)mmHg;DBP(-4.6±4.1)mmHg vs(0.92±2.2)mmHg;MBP(-4.8±3.9)mmHg vs(3.5±1.4)mmHg],差异均有统计学意义(P<0.05).夜间血压两组患者差异无统计学意义(P>0.05).结论 西地那非可用于顽固性高血压患者的治疗.

Clinical observation of sildenafil in patients with resistant hypertension

Objective To observe clinical effect of the sildenafil in patients with resistant hypertension. Methods A randomized, single-blinded, placebo-controlled clinical trial was adopted to divide 52 patients with resis-tant hypertension in Second Hospital Affiliated to Hainan Medical College from January 2013 to Oct 2016 into sildena-fil group (n=26) and placebo group (n=26). The treatment course of all the patients was 8 weeks. The 24-hour ambula-tory blood pressure changes before and after treatment were observed to evaluate the effect of sildenafil on resistant hy-pertension. Results After 8-week treatment, the reduction of 24-hour mean blood pressure of the patients in the silde-nafil group was significantly better than that in placebo group, systolic blood pressure (SBP) (-8.8±1.4) mmHg vs (1.3± 1.2) mmHg, diastolic blood pressure (DBP) (-5.3±3.3) mmHg vs (1.8±1.1) mmHg, mean blood pressure (MBP) (-7.9± 3.6) mmHg vs (0.8±0.9) mmHg. The daytime mean blood pressure of the patients in the sildenafil group was significant-ly better than that in placebo group, which were SBP (-6.0±4.7) mmHg vs (4.4±1.5) mmHg, DBP (-4.6±4.1) mmHg vs (0.92±2.2) mmHg, MBP (-4.8±3.9) mmHg vs (3.5±1.4) mmHg, showing the statistical differences (P<0.05). No statisti-cal difference in the nighttime mean blood pressure was found (P>0.05). Conclusion Sildenafil can effectively re-duce the artery blood pressure in patients with resistant hypertension.