黄芪颗粒预防脑动脉瘤介入治疗后相关对比剂肾病的临床研究

目的 探讨黄芪颗粒对脑动脉瘤患者行介入治疗后发生对比剂肾病(CIN)的预防作用.方法 选取广州医科大学附属第三医院神经外科2013年2月至2016年2月收治的患有脑动脉瘤行介入治疗的82例患者为研究对象,根据数表法随机分为对照组40例和观察组42例,对照组患者采用常规水化疗法,观察组在对照组基础上服用黄芪颗粒,比较两组患者术后肝功能情况、CIN发生率及血清超氧化物歧化酶(SOD)和丙二醛(MDA)情况.结果 观察组患者的CIN发生率为2.4%,低于对照组的7.5%,SOD浓度为(110.38±4.60)U/L,高于对照组的(96.62±3.75)U/L,MDA为(7.36±1.68)μmol/L,低于对照组的(10.49±2.16)μmol/L,以上各项指标比较差异均有统计学意义(P<0.05);两组患者术后肝功能比较差异均无统计学意义(P>0.05).结论 黄芪颗粒可降低脑动脉瘤介入治疗后相关对比剂肾病的发生率,保护肾功能,未对肝功能造成损害.

Clinical study of Astragalus granule in the prevention of contrast-induced nephropathy after interventional treatment of cerebral aneurysm.

Objective To investigate the preventive effects of Astragalus granule on the prevention of con-trast-induced nephropathy (CIN) after interventional treatment of cerebral aneurysm. Methods A total of 82 patients with cerebral aneurysm who underwent interventional treatment in Department of Neurosurgery in Third Affiliated Hospi-tal of Guangzhou Medical University from February 2013 to February 2016 were selected as the research objects. Accord-ing to the random number table, they were divided into two groups, control group (n=40), and observation group (n=42). The control group was treated with conventional water therapy, and observation group were given Astragalus granule based on the control group. The postoperative liver function, the incidence of CIN, the levels of serum superoxide dis-mutase (SOD) and malondialdehyde (MDA) were compared between the two groups. Results The incidence rate of CIN in observation group was 2.4%, which was significantly lower than 7.5%in the control group (P<0.05). The concen-tration of SOD was (110.38±4.60) U/L in observation group, which was significantly higher than (96.62±3.75) U/L in the control group (P<0.05). The concentration of MDA was (7.36±1.68)μmol/L in observation group, which was significantly lower than (10.49 ± 2.16)μmol/L in the control group (P<0.05). There was no significant difference in liver function be-tween the two groups (P>0.05). Conclusion Astragalus granule can reduce the incidence of CIN after interventional ther-apy of cerebral aneurysm, protect renal function, and cause no damage to liver function.