外周血NLR在无症状卵巢上皮癌早期诊断中的价值

目的 探讨外周血中性粒细胞/淋巴细胞比值(NLR)在卵巢上皮癌筛查和早期诊断中的价值.方法 选取2013年6月至2016年8月我院收治的卵巢上皮性癌患者71例(病例组)和健康对照组65例,比较两组间NLR水平,并通过ROC曲线及最佳诊断界值点(DCP)评估外周血NRL预测卵巢上皮癌的价值.结果 病例组患者的NLR水平(3.00±2.63)高于健康对照组(1.64±0.64),差异有显著统计学意义(P<0.01);NLR的ROC曲线下面积为0.727,最佳DCP为2.00,灵敏度、特异度、准确度、阳性预测值、阴性预测值分别为61.97%(44/71)、81.54%(53/65)、71.32%(97/136)、78.57%(44/56)、66.25%(53/80).结论 NLR对卵巢上皮癌的诊断具有一定价值,可用于卵巢上皮性肿瘤的初步筛查和早期诊断.

Value of peripheral blood NLR in early diagnosis of asymptomatic epithelial ovarian cancer

Objective To investigate the value of peripheral neutrophil-to-lymphocyte ratio (NLR) in screen-ing and early diagnosis of epithelial ovarian cancer. Methods A total of 71 patients of epithelial ovarian cancer and 65 cases of healthy controls were selected from June 2013 and August 2016. The level of NLR was compared among the two groups. The ROC curve and diagnostic critical point (DCP) were analyzed to evaluate the predictive value of NLR. Results The NLR in epithelial ovarian cancer group were significantly higher than that in healthy controls group, (3.00±2.63) vs (1.64±0.64), P<0.01. Area under the ROC curve for NLR levels was 0.727, and the cut-off value of DCP of NLR was 2.00, with the sensitivity of 61.97%(44/71), specificity of 81.54%(53/65), accuracy of 71.32%(97/136), positive predictive value of 78.57%(44/56), and negative predictive value of 66.25%(53/80). Conclusion The NLR is valuable for the diagnosis of ovarian epithelial carcinoma, which can be used for screening and early diagnosis of epithe-lial ovarian cancer.