济南地区中老年人群维生素D营养状况及其与血脂的关系

目的 了解济南地区中老年人群维生素D的营养状况,并探讨其与血脂的关系.方法 随机抽取2014年7月至2016年6月间山东大学附属省立医院体检的453例中老年人为研究对象,其中中年组107例,老年组346例,男性317例,女性136例.采用罗氏电化学发光免疫分析仪测定中老年人群血清25-羟维生素D(25-OHVitD)水平,Beckman AU5800全自动生化分析仪测定血脂指标(总胆固醇、甘油三脂、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇),并分析25-OHVitD水平与年龄、性别、季节及血脂的关系.结果 (1)中年组人群维生素D不足占54.21%,明显高于老年组的42.77%;中年组维生素充足占6.54%,明显低于老年组的13.58%,差异均有统计学意义(P<0.05);(2)在夏季,中老年人血清25-OHVitD不足占36.10%,明显低于春季的49.58%和秋季的58.82%,差异均有统计学意义(P<0.05);(3)25-OH VitD水平缺乏和不足(<20 ng/mL)时,血清25-OH VitD与甘油三酯呈负相关(r=-0.350,P<0.01).结论 济南地区中老年人群维生素D缺乏及不足比较普遍,在夏季维生素D不足状况有改善,维生素D缺乏不足与血清甘油三脂有关.

Vitamin D nutritional status and the relationship between Vitamin D and blood lipid levels in middle-aged and elderly people of urban residents in Jinan

Objective To explore the Vitamin D nutritional status and the relationship between Vitamin D and blood lipid levels in middle-aged and elderly people of urban residents in Jinan. Methods A total of 453 middle-aged and elderly people undergoing physical examination in our hospital from Jul. 2014 to Jun. 2016, including 107 mid-dle-aged and 346 elderly people, 317 men and 136 women, were selected by a random sampling. Serum 25-hydroxy vita-min D (25-OHVitD) level was measured by Roche electro chemiluminescence immunoassay analyzer, and blood lipid indexes (triglyceride TG], total cholesterol TC], high-density lipoprotein cholesterol HDL-C] and low-density lipopro-tein cholesterol LDL-C]) were detected by Beckman AU5800 automatic biochemical analyzer. The relationships be-tween 25-OHVitD levels and ages, gender, season and blood lipid levels were analyzed. Results The percent of Vita-min D insufficiency or sufficiency showed statistical difference in middle-aged people and in elderly people (54.21%vs 42.77%for insufficiency;6.54%vs 13.58%for sufficiency;both P<0.05). The percent of Vitamin D insufficiency in sum-mer was significantly lower than that in spring or autumn (36.10%in summer vs 49.58%in spring or 58.82%in autum, both P<0.05). People with less than 20 ng/mL 25-OHVitD showed a negative correlation between 25-OHVitD level and TG (r=-0.350, P<0.01). Conclusion Vitamin D deficiency and insufficiency are widely prevalent in Jinan residents, and Vitamin D showed increased levels in summer. People with the deficiency of 25-OHVitD showed negative correla-tion between 25-OHVitD level and TG.