| 桂莪术乙醇提取物及其挥发油对实验性肝损害的保护作用 |
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| 引用本文： | 相正心,何兴全,周桂芬,李翠红.桂莪术乙醇提取物及其挥发油对实验性肝损害的保护作用[J].中国中药杂志,1989,14(5):47-49. |
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| 作者姓名： | 相正心 何兴全 周桂芬 李翠红 |
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| 作者单位： | 广西中医药研究所,南宁 |
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| 摘 要： | 桂莪术醇提物及挥发油对CCI4、TAA引起小鼠SGPT升高有明显的降低作用,使BSP潴留量减少,相应肝组织病变减轻;对CCI4损害和正常小鼠戊巴比妥钠睡眠时间明显缩短,对甘油三酯有抑制作用。桂莪术的毒性较低,口服LD50醇提物为86.8±12g生药/kg,挥发油为1.10±0.08g/kg。
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| 关 键 词： | 桂莪术乙醇提取物 桂莪术挥发油 四氯化炭 硫代乙酰胺 血清谷丙转氨酶 |
Protective Effects of Ethanolic Extract and Essential oil of Curcuma Kwangsinensis S.against Experimental Liver Lesion in Mice |
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| Xiang Zhengxin,He Xingquan,Zhou Guifen Li Cuihong.Protective Effects of Ethanolic Extract and Essential oil of Curcuma Kwangsinensis S.against Experimental Liver Lesion in Mice[J].China Journal of Chinese Materia Medica,1989,14(5):47-49. |
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| Authors: | Xiang Zhengxin He Xingquan Zhou Guifen Li Cuihong |
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| Institution: | Guangxi Institute of Traditional Chinese Medical and Pharmaceutical Sciences Nanning |
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| Abstract: | The ethanolic extract and the essential oil of Curcuma kwangsinensis were found to be effective in lowering the elevated SGPT induced by CCl4, TAA and BSP retention. Histological examination showed that hepatic damages of the extract-and oil-pretreated mice were less than those of the CCl4, control group. The ethanolic extract helped to shorten sodium pentobarbital sleeping time in both normal and CCl4 intoxicated mice. In addition, the essential oil exhibited an inhibitory effect on triglyceride accumulation in mice. The toxicity of the extract and the oil was found to be low: oral LD50 was 86.8±12g crude drug/kg (ethanolic extract) and 1.10±0.08g/kg (essential oil). |
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| Keywords: | ethanolic extract and essential oil of Curcuma Kwangsinensis carbon tetrachloride thiacetamide serum glutamic-pyruvic transaminase |
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