| 戊四氮点燃癫癎大鼠海马5-羟色胺能神经递质的动态研究 |
| |
| 引用本文： | 陈文珍,王开颜,洪震,刘学源,陈玉娟.戊四氮点燃癫癎大鼠海马5-羟色胺能神经递质的动态研究[J].中国临床神经科学,2010,18(5):449-455. |
| |
| 作者姓名： | 陈文珍 王开颜 洪震 刘学源 陈玉娟 |
| |
| 作者单位： | 1. 同济大学附属第十人民医院,200072
2. 复旦大学附属华山医院,200040 |
| |
| 基金项目： | 国家自然科学基金面上项目 |
| |
| 摘 要： | 目的：观察戊四氮（PTZ）点燃癫癎形成过程中大鼠海马5-羟色胺（5-HT）能神经递质的变化。方法：用PTZ制作癫癎大鼠模型,将造模成功大鼠分为戊四氮急性发作组（PTZ 1组）和戊四氮慢性点燃组（PTZ 2组）,同时设立对照组（腹腔注射生理盐水）。在体微透析取样,观察大鼠行为、脑电图（EEG）和海马5-HT能神经递质的变化。结果：PTZ 1组癫癎发作时EEG自发放电逐级加重;癫癎发作时海马5-HT水平与对照组、发作前和发作后比较显著升高（P〈0.05）;海马5-羟吲哚乙酸（5-HIAA）水平差异无统计学意义;5-HT转化率（5-HIAA/5-HT）降低,差异有统计学意义（P〈0.05）。PTZ 2组点燃后大鼠出现自发癫癎发作,EEG在发作间期出现自发放电;5-HT和5-HIAA水平在点燃期、维持点燃期、对照组间比较差异有统计学意义（P〈0.05）。结论：大鼠癫癎发作时海马5-HT水平显著升高,发作后恢复正常;在癫癎形成过程中,早期5-HT水平一过性升高、PTZ点燃后和发作间期海马5-HT水平逐渐降低。
|
| 关 键 词： | 戊四氮 癫癎 微透析 海马 5-羟色胺 |
Rats Hippocampus 5-HT-energic Variance in PTZ-induced Kindling Epilepsy |
| |
| CHEN Wen-Zhen,WANG Kai-Yan,HONG Zhen,LIU Xue-Yuan,CHEN Yu-Juan.Rats Hippocampus 5-HT-energic Variance in PTZ-induced Kindling Epilepsy[J].Chinese Journal of Clinical Neurosciences,2010,18(5):449-455. |
| |
| Authors: | CHEN Wen-Zhen WANG Kai-Yan HONG Zhen LIU Xue-Yuan CHEN Yu-Juan |
| |
| Institution: | CHEN Wen-Zhen~1,WANG Kai-Yan~2,HONG Zhen~2,LIU Xue-Yuan~1,CHEN Yu-Juan~1 1 Department of Neurology,the tenth People's Hospital of Tongji University,Shanghai 200072,2 Department of Neurology,Huashan Hospital,Fudan University,Shanghai 200040,China |
| |
| Abstract: | Aim:To investigate the variance of 5-HT energic neurotransmitter in pentylenetrazol induced kindling epilepsy rats hippocampus.Methods:Epilepsy rat models were made by PTZ,and the rats were divided into PTZ acute group(PTZ 1 group) and PTZ-induced kindling group(PTZ 2 group),the control group was set up at the same time.Microdialysis was done in vivo.The rats' behavior,their EEG and the changes of hippocampus 5-HT were observed.Results:In PTZ 1 group,EEG showed gradually aggravated epileptic discharge with ... |
| |
| Keywords: | pentylenetrazol epilepsy microdialysis hippocampus 5-hydroxytryptamine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
