人乳头瘤病毒与女性生殖道病原体感染相关性分析

目的探讨妇女生殖道人乳头瘤病毒(HPV)感染与生殖道其他病原体感染的相互关系及危险因素分析。方法共计950名伴有各种生殖道感染症状与体征的妇女,病原体的检测包括阴道滴虫、白色念珠菌、沙眼衣原体、解脲支原体、淋病奈瑟菌、HPV和梅毒。用单因素Logistic回归分析HPV感染与其他生殖道病原体感染的相关性。结果生殖道HPV6、11感染合并解脲支原体阳性检出率较高,HPV6、11感染与解脲支原体感染有明显相关性(P=0.01),HPV6、11、16、18感染与解脲支原体(P=0.02),沙眼衣原体(P=0.04),梅毒(P=0.01)感染有一定的相关危险性。结论妇女生殖道HPV感染与解脲支原体、沙眼衣原体、梅毒的感染有关。HPV与生殖道病原体感染相互作用的机制值得进一步探讨。

Study for reproductive tract with human papillomaviruses and other pathogen infection on women

Objective To explore the relationship for women with reproductive tract human papillomaviruses (HPV) infection and other reproductive tract pathogen infection. Method There were 950 women with reproductive tract infection symptoms to join it. Pathogen examinations were done and which included vagina trichomonad, candida albicans, chlamydia trachomatis, ureaplasma urealyticu, gonorrhoea, HPV6,11,16,18 and syphilis. The single factor logistic recurrence analysis was used, and the relationship of women with HPV6,11,16,18 infection and other reproductive tract pathogen infection was analysed. Results The positive rate of reproductive tract infection HPV6,11 combining ureaplasma urealyticu infection was high. The correlation between HPV6,11 infection and ureaplasma urealytic infection was evident(P=0.01). There were certain correlations between reproductive tract infection HPV6,11,16,18 infection and other reproductive tract pathogeny infection, and which was ureaplasma urealytic infection (P=0.02), chlamydia trachomatis infection(P=0.04) and syphilis infection(P=0.01). Conclusions The reproductive tract HPV infection on women is related to ureaplasma urealytic infection, chlamydia trachomatis infection and syphilis infection. The mechanism between HPV and other reproductive tract pathogen infection is worth to be probed in further.