Inhibition of rat brain monoamine oxidase activity by cerebral anti-ischemic agent, ifenprodil |
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| Authors: | Y Arai K Nakazato H Kinemuchi T Tadano N Satoh K Oyama K Kisara |
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| Institution: | Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan. |
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| Abstract: | Ifenprodil, which is clinically used as a cerebral vasodilator, inhibited rat brain type A (MAO-A) and type B (MAO-B) monoamine oxidase activity. It did not, however, affect rat lung semicarbazide-sensitive amine oxidase. The degree of inhibition of either form of MAO was not changed by 30 min preincubation of the enzyme preparations at 37 degrees C with ifenprodil. Modes of inhibition of MAO-A and MAO-B by ifenprodil were competitive towards oxidation of their respective substrates, 5-hydroxytryptamine and benzylamine, with Ki values of 75 microM for inhibition of MAO-A and 110 microM for inhibition of MAO-B. |
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