发现毒理学的研究进展

发现毒理学又称为开发前毒理学(Predevelopmental Toxicology),是指在创新药物的研发早期,对所合成的系列新化合物实体(New Chemical Entities, NCEs)进行毒性筛选,以发现和淘汰因毒性问题而不适于继续研发的化合物,指导合成更安全的同类化合物.发现毒理学的研究既可加快药物研发进程,提高研发成功率,又减少资源消耗.笔者就发现毒理学研究的定义、必要性、研究内容、研究方法和我国当前的研究现状作一简述.

Progresses of discovery toxicology research

Discovery toxicology, also named predevelopmental toxicology, is to screen toxicities of new chemical entities (NCEs) in the discovery phase of new drug research,to discover and eliminate the compounds that are unsuitable for further development due to their toxicity as early as possible,and to optimize the next more safe compounds. Discovery toxicology research can break through the limitation and improve the efficiency of drug research. This article will present the concept of discovery toxicology, the essentiality of discovery toxicology research. The content, methods and current status of discovery toxicology in China are described too.