Development of macrolide resistance by ribosomal protein L4 mutation in Streptococcus pyogenes during miocamycin treatment of an eight-year-old Greek child with tonsillopharyngitis |
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| Authors: | B. Bozdogan P. C. Appelbaum L. Ednie I. N. Grivea G. A. Syrogiannopoulos |
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| Affiliation: | Hershey Medical Center, Department of Pathology, Hershey, PA, USA and;Deparment of Pediatrics, University of Patras, School of Medicine, Patras, Greece;Tel: +1 717 531 5113 Fax: +1 717 531 7953 E-mail: |
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| Abstract: | Streptococcus pyogenes isolates with the same pulsed-field patterns were recovered from the throat cultures of a child with tonsillopharyngitis before and after treatment with miocamycin, a 16-membered macrolide. The initial isolate was macrolide-susceptible, but the isolates after the treatment were resistant to 14 and 15-membered macrolides and had two amino acid (65WR66) deletions in ribosomal protein L4. |
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| Keywords: | Streptococcus pyogenes macrolide resistance ribosomal mutation |
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