BK polyomavirus encephalitis in a patient with thrombotic microangiopathy after an allogeneic hematopoietic stem cell transplant |
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| Authors: | Jae‐Bum Jun Yunsuk Choi Hawk Kim Sun Ho Lee Joseph Jeong Jiwon Jung |
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| Affiliation: | 1. Division of Infectious Diseases, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea;2. Division of Hematology and Cellular Therapy, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea;3. Department of Laboratory Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea |
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| Abstract: | To date, only one case of BK polyomavirus (BKPyV) encephalitis combined with transplant‐associated thrombotic microangiopathy has been reported in an hematopoietic stem cell transplantation (HCT) recipient. We report the case of an HCT recipient who developed thrombotic microangiopathy and subsequent BKPyV encephalitis. She died despite treatment with cidofovir, ciprofloxacin, and intravenous immunoglobulin without improvement in mental status. Early suspicion of BKPyV encephalitis in an HCT recipient presenting with altered mental status and hemorrhagic cystitis is important. |
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| Keywords: | BK virus cidofovir encephalitis hematopoietic stem cell transplantation transplant‐associated thrombotic microangiopathy |
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