| Effects of Tangshenkang Capsule(糖肾康胶囊) on Disbetic Nephropathy |
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| 引用本文： | 郭宝瑞,刘喜新,韩清,王宪波,桑雁.Effects of Tangshenkang Capsule(糖肾康胶囊) on Disbetic Nephropathy[J].Chinese Journal of Integrated Traditional and Western Medicine,1997(1). |
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| 作者姓名： | 郭宝瑞 刘喜新 韩清 王宪波 桑雁 |
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| 作者单位： | The First Affiliated Hospital of Xinxiang Medical College，Henan 453100 |
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| 摘 要： | ＥｆｆｅｃｔｓｏｆＴａｎｇｓｈｅｎｋａｎｇＣａｐｓｕｌｅｏｎＤｉｓｂｅｔｉｃＮｅｐｈｒｏｐａｔｈｙ￥ＷＡＮＧＸｉａｎ－ｂｏ；ＳＡＮＧＹａｎ；ＨＡＮＱｉｎｇＧＵＯＢａｏ－ｒｕｉａｎｄＬＩＵＸｉ－ｘｉｎ（ＴｈｅＦｉｒｓｔＡｆｆｉｌｉａｔｅｄＨｏｓｐｉｔａ...
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Effects of Tangshenkang Capsule on Disbetic Nephropathy |
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| Authors: | WANG Xian-bo SANG Yan HAN QingGUO Bao-ruiand LIU Xi-xin |
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| Abstract: | Objective: To study the effects of Chinese herbal medicine Tangshenkang (TSK) capsule on diabetic nephropathy (DN). Method: Fifty-seven patients with DN were randomly divided into two groups, the TSK-treated group and the control group. Results: Serious disorders of metabolism showed in DN patients, displayed high levels of thromboxane B2 / 6 - keto- prostaglandin F1a (TXB2 / 6-keto-PGF1a ) ratio and lipid peroxide (LPO) as compared with those of healthy persons. After 6 weeks treatment with TSK, the urinary albumin level reduced obviously (by 51 % ), renal plasma flow (RPF) increased, glomerular filtration rate and LPO levels decreased. A positive correlation was observed between albuminuria level and TXB2/6-keto-PGF1a ratio. The clearance rate of creatinine didn't improve significantly. In the control group, no significant difference in the above-mentioned parameters between pre-treatment and post-treatment was found. Conclusion: TSK capsule possessed a significant effect in improving urinary albumin and glomerular function. These effects might be due to the property of TSK in adjusting TXB2/6-keto-PGF1a ratio and its lipid-peroxidation in DN patients. |
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| Keywords: | Tangshenkang capsule diabetic nephropathy thromboxane B_2 6-keto-prostaglandin F_(1a) lipid peroxide |
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