| 刺五加叶皂甙对Ⅱ型糖尿病大鼠GLP-1和血糖分泌的影响 |
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| 引用本文： | 李艳君,欧叶涛,李晓涛,扈清云,杨扬,姜吉文. 刺五加叶皂甙对Ⅱ型糖尿病大鼠GLP-1和血糖分泌的影响[J]. 解剖科学进展, 2003, 9(3): 238-239 |
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| 作者姓名： | 李艳君 欧叶涛 李晓涛 扈清云 杨扬 姜吉文 |
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| 作者单位： | 佳木斯大学基础医学院解剖教研室,黑龙江,佳木斯,154007 |
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| 摘 要： | 目的 研究刺五加叶皂甙 (acanthopanaxsenticosussaponin ,Ass)对实验性Ⅱ型糖尿病 (非胰岛素依赖型糖尿病 ,non insulindependentdiabetesmellitus,NIDDM)大鼠胰高血糖素样肽 1(glucagon likepeptide 1,Glp 1)和血糖的作用。方法 选用雄性Wistar大鼠 5 0只 ,用链尿佐菌素 2 5mg/kg加高脂、高糖、高热量饲养制成Ⅱ型糖尿病大鼠模型。应用放射免疫分析测定给予Ass后其空腹及口服葡萄糖后血浆中Glp 1和血糖变化。 结果 与正常组大鼠比较 ,Ass可使Ⅱ型糖尿病大鼠空腹及口服葡萄糖后Glp 1分泌升高、血糖水平降低。 结论 Ass对Ⅱ型糖尿病大鼠具有一定的治疗作用
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| 关 键 词： | 刺五加叶皂甙 大鼠 胰高血糖素样肽-1 血糖 |
| 文章编号： | 1006-2947(2003)03-0238-02 |
| 修稿时间： | 2002-09-24 |
Effects of Ass Glp-1 and Blood Glucose in Experimental NIDDM Rats |
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| LI Yan jun,OU Ye tao,LI Xiao tao,et al. Effects of Ass Glp-1 and Blood Glucose in Experimental NIDDM Rats[J]. Progress of Anatomical Sciences, 2003, 9(3): 238-239 |
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| Authors: | LI Yan jun OU Ye tao LI Xiao tao et al |
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| Abstract: | Objective To study the effects of acanthopanax senticosus saponin (Ass) on the levels of glucagon like peptide 1 (Glp 1) and blood glucose in experimental non insulin dependent diabetes mellitus(NIDDM) rats. Methods 50 male wistar rats were injected with STZ (25 mg/kg) via tail vein and fed on diet of high fat, high glucose and high calorie, the levels of Glp 1 and blood glucose were determined by radioimmunoassay. Results ASS can increase Glp 1 secretion, decrease the blood glucose secretion in NIDDM rats, no action in normal rats. Conclusion |
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| Keywords: | ASS rats Glp 1 blood glucose secretion in NIDDM rats |
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