| 应答式释药系统构建方法的研究进展 |
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| 引用本文： | 王芳,郑琴,伍振峰,岳鹏飞,胡鹏翼,薛鑫,杨明. 应答式释药系统构建方法的研究进展[J]. 中国中药杂志, 2013, 38(22): 3801-3807 |
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| 作者姓名： | 王芳 郑琴 伍振峰 岳鹏飞 胡鹏翼 薛鑫 杨明 |
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| 作者单位： | 江西中医学院 现代中药制剂教育部重点实验室, 江西 南昌 330004;成都中医药大学, 四川 成都 610075;江西中医学院 现代中药制剂教育部重点实验室, 江西 南昌 330004;江西中医学院 现代中药制剂教育部重点实验室, 江西 南昌 330004;成都中医药大学, 四川 成都 610075;江西中医学院 现代中药制剂教育部重点实验室, 江西 南昌 330004;江西中医学院 现代中药制剂教育部重点实验室, 江西 南昌 330004;江西中医学院 现代中药制剂教育部重点实验室, 江西 南昌 330004;江西中医学院 现代中药制剂教育部重点实验室, 江西 南昌 330004 |
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| 基金项目： | 国家自然科学基金项目(81102821);江西省自然科学基金项目(20114BAB215042);江西省教育厅青年基金项目(GJJ12533);江西省卫生厅中医药科研计划项目(2010A091) |
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| 摘 要： | 应答式释药系统能在特定时间、位点并根据生物节律变化释放药物,有效克服了机体耐药性,具有保护药物、局部靶向、抑制酶活性及记忆与表达等优点,具有良好的应用前景,目前已有多个化药制剂品种上市。该文主要综述了该释药系统构建方法的研究进展,同时考虑复杂中药(复方)中多组分、多环节、多靶点的整体作用特点,尝试提出了基于中药组分应答式释药系统的研究思路,以期"抛砖引玉",为该递药系统的发展提供借鉴与思考。
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| 关 键 词： | 应答释药 生物节律 外调式释药 自调式释药 脉冲释药 中药组分 |
| 收稿时间： | 2013-04-22 |
Advance in studies on establishment methods of responsive drug delivery system |
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| WANG Fang,ZHENG Qin,WU Zhen-feng,YUE Peng-fei,HU Peng-yi,XUE Xin and YANG Ming. Advance in studies on establishment methods of responsive drug delivery system[J]. China Journal of Chinese Materia Medica, 2013, 38(22): 3801-3807 |
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| Authors: | WANG Fang ZHENG Qin WU Zhen-feng YUE Peng-fei HU Peng-yi XUE Xin YANG Ming |
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| Affiliation: | Key Lab of Modern Preparations of Traditional Chinese Medicine under Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China;Key Lab of Modern Preparations of Traditional Chinese Medicine under Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Key Lab of Modern Preparations of Traditional Chinese Medicine under Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China;Key Lab of Modern Preparations of Traditional Chinese Medicine under Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Key Lab of Modern Preparations of Traditional Chinese Medicine under Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Key Lab of Modern Preparations of Traditional Chinese Medicine under Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Key Lab of Modern Preparations of Traditional Chinese Medicine under Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China |
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| Abstract: | Responsive drug delivery system can release drug at specific time and sites, and effectively overcome the drug resistance of organisms. With such advantages as drug protection, local targeting, inhibition of enzymatic activity, memory and expression, it has good prospect of application. So far, many chemical preparations have been launched in the market. This article mainly summarizes the advance in studies on establishment methods of responsive drug delivery system, while proposing research ideas for the traditional Chinese medicine component-based responsive drug delivery system according to the multi-component, multi-link and multi-target characteristics, in the expectation of providing reference and thought for the development of the drug delivery system. |
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| Keywords: | responsive drug delivery systems biological rhythm externally regulated drug delivery self-regulated drug delivery pulsed drug delivery components of traditional Chinese medicine |
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