Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines |
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| Authors: | Matsumoto Kenji Akao Yukihiro Kobayashi Emi Ohguchi Kenji Ito Tetsuro Tanaka Toshiyuki Iinuma Munekazu Nozawa Yoshinori |
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| Affiliation: | Gifu International Institute of Biotechnology, 1-1 Naka-Fudogaoka, Kakamigahara, Gifu 504-0838, Japan. kmatsumoto@giib.or.jp |
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| Abstract: | We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis. |
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