区域性动脉灌注化疗中5-氟脲嘧啶在大鼠血液和胰腺组织中的分布

目的观察并比较区域性动脉灌注和静脉推注中５－氟脲嘧啶（５－ＦＵ）的吸收、分布和消除过程，为临床区域性动脉灌注化疗提供实验室依据。方法将Ｗｉｓｔａｒ大鼠随机分为全身静脉给药组和区域性动脉灌注组，用高效液相色谱法分别测定两组血浆和胰腺组织中的５－ＦＵ浓度，并计算穿透指数和治疗优势度。结果静脉推注组胰腺组织中５－ＦＵ的最大浓度（Ｃｍａｘ）为８．４２ｕｇ／ｇ，存留时间为５０ｍｉｎ；区域性动脉灌注组胰腺组织中５－ＦＵ的Ｃｍａｘ为２０．００ｕｇ／ｇ，存留时间为９０ｍｉｎ，皆明显高于静脉推注组（Ｐ＜０．０５）。治疗优势度为２．４２。结论区域性动脉灌注５－ＦＵ能提高胰腺组织中５－ＦＵ浓度，延长胰腺癌组织和转移灶在５－ＦＵ中的暴露时间，改善治疗效果。

Distribution of 5-fluorouracil in Plasma and Pancreatic Tissue of Rats during the Regional Arterial Infusion Chemotherapy

Compare the pharmacokinetic parameters of 5-FU in the regional arterial infusion chemotherapy with those in the intravenous chemotherapy. Methods Wistar rats wererandomly divided into two groups: the intravenous group and the regional arterial infusiongroup. HPLC was used to measure the concentration of 5-FU in the plasma and the pancreas tissue. Penetration index was calculated. Results in the intravenous group, maximum concentration (Cmax) of 5-FU in the pancreas was 8. 42 ug/g and the clearance time of the pancreas was50 min. In the regional arterial infusion group, Cmax of 5-FU in the pancreas was 20. 00 ug/gand the clearance time of the pancreas was 90 min. They were both greater than those of the intravenous group. Rd was 2. 42. Conclusions The regional arterial infusion chemotherapy is abetter way for treating pancreatic carcinoma than the intravenous chemotherapy.