| 镁对脑缺血早期神经元保护机制的初步研究 |
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| 引用本文： | 邓学军,孙圣刚,童萼塘. 镁对脑缺血早期神经元保护机制的初步研究[J]. 卒中与神经疾病, 1999, 6(3): 142-144 |
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| 作者姓名： | 邓学军 孙圣刚 童萼塘 |
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| 作者单位： | 同济医大附属协和医院神经科 |
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| 摘 要： | 目的：探讨Ｍｇ＾２＋对脑缺血早期神经元保护机制。方法：利用阻塞胡防中动脉制造局灶性脑缺血模型，观察缺血后Ｍｇ＾２＋对海马区谷氨酸含量的影响，利用透射电镜观察Ｍｇ＾２＋对海马ＣＡ１区神经元超微结构的影响。结果：大剂量Ｍｇ＾２＋可显著降低Ｇｌｕ含量，且能减轻缺血后海马ＣＡ１区神经元的损害。
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| 关 键 词： | 硫酸镁 脑缺血 谷氨酸 透射电镜 神经元保护 |
Investigation of the protective mechanism of magnesium of neuron of early stage after focal cerebral ischemia |
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| Deng Xuejun,Sun Shenggang,Tong Etong. Investigation of the protective mechanism of magnesium of neuron of early stage after focal cerebral ischemia[J]. Stroke and Nervous Diseases, 1999, 6(3): 142-144 |
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| Authors: | Deng Xuejun Sun Shenggang Tong Etong |
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| Affiliation: | Deng Xuejun,Sun Shenggang,Tong Etong. Department of Neurology,Union Hospital,Tongji Medical University Wuhan 430022 |
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| Abstract: | Objective:To investigate the protective machanism of magnesium(Mg 2 ) on the neuron of early stage after focal cerebral ischemia.Methods:The model of focal cerebral ischemia by occluding middle artary in rats was used to investigate the effects of Mg 2 on volume of glutamate in hippocampal and the microstructure of hippocampal CA 1 neuron.Results:Mg 2 could significantly decrease the volume of glutamate in hippocampal and attenuate the damage of neuron.Conclusion:Mg 2 may protect the neuron by reducing the volume of glutamate. |
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| Keywords: | Magnesium Cerebral ischemia Glutamate Hippocamal CA 1 Electromicroscope |
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