Risk of suicide in mood disorders |
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| Institution: | 1. Department of Urology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China;2. Department of mechanical engineering, National University of Singapore, Kent Ridge, Singapore;1. Institute of Child Development, University of Minnesota, Minneapolis, MN, USA;2. Department of Psychology, University of Oregon, Eugene, OR, USA;3. Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA;1. University of Florida & Wolfson Children Hospital, Jacksonville, FL, USA;2. Nemours Children Health System, Jacksonville, FL, USA;3. Mayo Clinic, Jacksonville, FL, USA;1. Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada;2. Department of Supportive Care, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada;1. Département de Psychiatrie de l''Enfant et de l''Adolescent, CHU d''Angers, France;2. Fondation de Santé des Étudiants de France, clinique de Sablé sur Sarthe, Sablé sur Sarthe, France;3. Département de Psychiatrie et Addictologie, CHU d''Angers, France;4. Univ. Angers, [CHU Angers], LPPL EA4638, F-49000 Angers, France;1. Universidad del País Vasco/Euskal Herriko Unibertsitatea, Spain;2. Department of Psychiatry, Araba University Hospital, Bioaraba Research Institute, Vitoria-Gasteiz, Spain;3. Department of Psychiatry, University of Oviedo, Oviedo, Spain;4. Networking Center for Biomedical Research in Mental Health (CIBERSAM), Spain;5. Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain;6. Mental Health Services of Principado de Asturias (SESPA), Oviedo, Spain |
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| Abstract: | Suicide is commonly associated with mood disorders. Risk factors for suicide in mood disorders can be organized according to whether their effect is on the threshold or diathesis for suicidal acts or whether they serve mainly as triggers or precipitants of suicidal acts. Predisposition to suicidal behavior or diathesis is a key element that helps to differentiate patients who are at high risk versus those at lower risk. The objective severity of mood disorders does not identify depressed patients at high risk for suicide attempt. There is a lack of agreement over the suicide risk associated with characteristics of depression such as psychotic features, agitation, or anxiety, or mixed mood states as part of bipolar disorder. Risk factors affecting the diathesis for suicidal behavior include family history of suicide, low cerebrospinal fluid 5-hydroxyindolacetic acid, alcohol and/or substance abuse, cluster B personality disorder, high past impulsivity and aggression, chronic physical illness particularly involving the brain, marital isolation, parental loss before age 11, childhood history of physical and sexual abuse, hopelessness, and not living with a child under age 18. Most common precipitants of suicidal acts in mood disorders include interpersonal losses or conflicts, financial trouble, and job problems. Identification of high risk patients and effective treatment are required for suicide prevention to reduce morbidity and mortality in affective disorders. |
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