Psychopharmacologic strategies for the prevention of suicidal behavior in bipolar patients |
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| Institution: | 1. The Menninger Clinic, 12301 Main Street, Houston, TX 77035, United States;2. Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States;3. University of Houston, United States;4. University of Hawaii, 200 West Kawili St., Hilo, HI 96720, United States;1. Janet E. Pope: Schulich School of Medicine, University of Western Ontario, St. Joseph''s Health Care, London, ON, Canada;2. Ernest H. Choy: Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom |
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| Abstract: | Current pharmacological strategies for the prevention of the suicide behavior in bipolar patients are reviewed. Additionally, these studies are discussed in the context of a stress–diathesis model, to explore whether this model explains the empirical fact that some drugs appear to have antisuicidal properties while others do not. A review of the relevant literature suggests that lithium and serotonin enhancing antidepressants reduce suicidal behavior in bipolar patients. A stress–diathesis model explains the differential effect of such medications compared to other antidepressants or mood stabilizers by proposing additional effects of these medications on the diathesis for suicidal behavior. This effect may be mediated by augmentation of serotonergic function, which is linked to suicidal behavior. Serotonergic enhancing drugs therefore can potentially reduce suicidal behavior. |
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