Telomerase: diagnostics,cancer therapeutics and tissue engineering |
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| Affiliation: | 1. Department of Microbiology and Biotechnology, Bangalore University;2. Department of Epidemic Disease Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia;3. Department of Biotechnology and Genetics, Ramaiah College of Arts, Science & Commerce, Bengaluru;4. Department of Biotechnology, Reva Institute, Bangalore, India;5. National Centre for Biotechnology, King Abdulaziz City for Science and Technology (KACST), PO Box 6086, Riyadh 11442, Saudi Arabia;6. Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia;7. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia;8. Department of Applied Bioscience, College of Life and Environmental Sciences, Konkuk University, Seoul 05029, Republic of Korea;1. Applied Physical Chemistry, Faculty of Science, Al-Azhar University (Girls), Cairo, Egypt;2. Al-Azhar Technology Incubator (ATI), Cairo, Egypt;3. Cancer Cell Biology, Zoology Department, Faculty of Science, Cairo University, Giza, Egypt;4. Zoology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt |
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| Abstract: | The enzyme telomerase has a key role in controlling the lifespan of human cells. It is absent from most somatic tissues but is reactivated in more than 85% of cancers, making the enzyme ideal as a marker of cancer cells and as a therapeutic target. In the context of normal human cells, the enzyme can extend cellular lifespan without causing cancer-associated changes or altering phenotypic properties. This capability could solve a major obstacle in the use of normal human cells for tissue engineering, that is, the induction of cellular senescence. |
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