止痛灵的镇痛抗炎作用 |
| |
引用本文: | 单忠 贾敏. 止痛灵的镇痛抗炎作用[J]. 西北药学杂志, 1995, 10(3): 115-117 |
| |
作者姓名: | 单忠 贾敏 |
| |
摘 要: | 灌胃给止痛灵268.5或537.1mg/kg,能显著抑制小鼠冰醋酸扭体反应,并提高热板法的小鼠痛阈值(P<0.05或P<0.01);134.3,268.5和537.1mg/kg均能抑制小鼠巴豆油所致耳壳肿胀度(P<0.05或P<0.01);268.5和537.1mg/kg对大鼠蛋清性足跖肿胀度有抑制作用(P<0.05或P<0.01);537.1mg/kg对大鼠肉芽肿的形成亦有抑制效果(P<0.05)。止痛灵ig小鼠LD50为2.69g/kg,而阿司匹林ig小鼠LD50为1.36g/kg。研究表明:止痛灵具有较强的镇痛、抗炎作用,且毒性较阿司匹林低。
|
关 键 词: | 止痛灵;镇痛;抗炎 |
Analgesic and anti-inflammatory effects ofZhitongling (ethenzamide ) |
| |
Abstract: | Taken in Zhitongling (268. 5 or 537. 1mg/kg), that can inhibit themouse reaction of glacial acetic acid significantly, and can raise its pain threshold of thehot-plate way (P<0.05 or P<0.01). Taken in the drug(134.4) 268. 5 and 537. 1mg/kgrespectively), those all can inhibit the swelling level of mouse auricle caused by croton oil(P<0.05 or P<0.01). 268. 5 and 537. 1mg/kg, so do in the eggwhite-like swelling level of the rat feet (P<0.05 or P<0.01); 537. 3mg/kg also inhibits the formation of ratgranulation. LD50 of Zhitongling in is 2. 69g/kg to the mouse. LD50 of Aspirin is 1.36g/kg. The results indicate: Zhitongling has stronger analgesic and anti-inflammatory effects; and the toxicity is lower than Aspirin. |
| |
Keywords: | Zhitongling(ethenzamide) analgesic anti-inflammatory |
本文献已被 维普 等数据库收录! |