| 止痛灵的镇痛抗炎作用 |
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| 引用本文： | 单忠,贾敏.止痛灵的镇痛抗炎作用[J].西北药学杂志,1995,10(3):115-117. |
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| 作者姓名： | 单忠 贾敏 |
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| 摘 要： | 灌胃给止痛灵２６８．５或５３７．１ｍｇ／ｋｇ，能显著抑制小鼠冰醋酸扭体反应，并提高热板法的小鼠痛阈值（Ｐ＜０．０５或Ｐ＜０．０１）；１３４．３，２６８．５和５３７．１ｍｇ／ｋｇ均能抑制小鼠巴豆油所致耳壳肿胀度（Ｐ＜０．０５或Ｐ＜０．０１）；２６８．５和５３７．１ｍｇ／ｋｇ对大鼠蛋清性足跖肿胀度有抑制作用（Ｐ＜０．０５或Ｐ＜０．０１）；５３７．１ｍｇ／ｋｇ对大鼠肉芽肿的形成亦有抑制效果（Ｐ＜０．０５）。止痛灵ｉｇ小鼠ＬＤ５０为２．６９ｇ／ｋｇ，而阿司匹林ｉｇ小鼠ＬＤ５０为１．３６ｇ／ｋｇ。研究表明：止痛灵具有较强的镇痛、抗炎作用，且毒性较阿司匹林低。
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| 关 键 词： | 止痛灵 镇痛 抗炎 |
Analgesic and anti-inflammatory effects ofZhitongling (ethenzamide ) |
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| Abstract: | Taken in Zhitongling (268. 5 or 537. 1mg/kg), that can inhibit themouse reaction of glacial acetic acid significantly, and can raise its pain threshold of thehot-plate way (P<0.05 or P<0.01). Taken in the drug(134.4) 268. 5 and 537. 1mg/kgrespectively), those all can inhibit the swelling level of mouse auricle caused by croton oil(P<0.05 or P<0.01). 268. 5 and 537. 1mg/kg, so do in the eggwhite-like swelling level of the rat feet (P<0.05 or P<0.01); 537. 3mg/kg also inhibits the formation of ratgranulation. LD50 of Zhitongling in is 2. 69g/kg to the mouse. LD50 of Aspirin is 1.36g/kg. The results indicate: Zhitongling has stronger analgesic and anti-inflammatory effects; and the toxicity is lower than Aspirin. |
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| Keywords: | Zhitongling(ethenzamide) analgesic anti-inflammatory |
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