| 哺乳动物腺苷酸环化酶亚型的研究进展 |
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| 引用本文： | 黄丽妹,朱建梁,孙敏. 哺乳动物腺苷酸环化酶亚型的研究进展[J]. 国际病理科学与临床杂志, 2011, 31(2): 161-166. DOI: 10.3969/j.issn.1673-2588.2011.02.015 |
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| 作者姓名： | 黄丽妹 朱建梁 孙敏 |
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| 作者单位： | 安徽大学生命科学学院,安徽省中药研究与开发重点实验室,合肥,230039 |
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| 基金项目： | 安徽省自然基金资助，安徽省研究实验基地优秀中青年科研带头人专项资金，国家中医临床研究基地糖尿病重点研究病种 |
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| 摘 要： | 腺苷酸环化酶(adenylyl cyclase,AC)作为G蛋白偶联受体(G protein-coupled receptors,GPCRs)下游的关键信号分子,参与了多种生理和病理进程.由于存在多种AC亚型(AC1～9及sAC),且各个膜型AC亚型在组织及不同细胞膜微区(脂筏)的分布、定位、活性及表达水平不尽一致,目...
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| 关 键 词： | 腺苷酸环化酶 脂筏 信号转导 G蛋白偶联受体 |
Research progress of adenylyl cyclase isoforms in mammals |
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| HUANG Limei,ZHU Jianliang,SUN Min. Research progress of adenylyl cyclase isoforms in mammals[J]. Journal of International Pathology and Clinical Medicine, 2011, 31(2): 161-166. DOI: 10.3969/j.issn.1673-2588.2011.02.015 |
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| Authors: | HUANG Limei ZHU Jianliang SUN Min |
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| Affiliation: | HUANG Limei,ZHU Jianliang,SUN Min(School of Life Science,Anhui University,Anhui Province Key Laboratory of R&D of Chinese Medicine,Hefei 230039,China) |
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| Abstract: | Adenylyl cyclase(AC),as a key downstream signaling molecule of G protein-coupled receptors(GPCRs),is involved in a variety of potential physiological and pathological processes.So far,at least nine membrane isoforms(AC1-9) and a soluble adenylyl cyclase(sAC) have been cloned and characterized in mammals,thus the research of AC isoforms has become increasingly complex.In this article we will review the research progress on the distribution,location,activity,and expression of AC isoforms in different tissues ... |
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| Keywords: | adenylyl cyclase lipid rafts signal transduction G protein-coupled receptors |
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