| 阿霉素诱导心肌细胞死亡机制 |
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| 引用本文： | 张懿玮,李元建.阿霉素诱导心肌细胞死亡机制[J].国际病理科学与临床杂志,2011,31(2):129-134. |
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| 作者姓名： | 张懿玮 李元建 |
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| 作者单位： | 中南大学药学院,长沙,410078 |
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| 摘 要： | 阿霉素是目前最为有效的抗肿瘤药物之一,其主要的严重副作用是累积性、剂量依赖性的心肌毒性反应,可进一步发展成不可逆性心肌损伤,最终导致充血性心力衰竭.心肌细胞凋亡和坏死被认为是阿霉素诱导心肌病变发展过程中的主要因素,自我吞噬和细胞老化等其他细胞死亡方式也参与此过程.阿霉素诱导心肌细胞死亡的机制可能包括:氧化应激以及由此发...
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| 关 键 词： | 阿霉素 心肌病变 细胞凋亡 细胞坏死 自我吞噬 |
Recent insights into doxorubicin-induced cardiomyocyte death |
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| ZHANG Yiwei,LI Yuanjian.Recent insights into doxorubicin-induced cardiomyocyte death[J].Journal of International Pathology and Clinical Medicine,2011,31(2):129-134. |
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| Authors: | ZHANG Yiwei LI Yuanjian |
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| Institution: | ZHANG Yiwei,LI Yuanjian(School of Pharmaceutical Sciences,Central South University,Changsha 410078,China) |
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| Abstract: | Doxorubicin(DOX) is one of the most widely used and successful antitumor drugs.The major side effect of DOX treatment is cumulative,dose-dependent cardiac toxicity and irreversible myocardial damage which results in refractory congestive heart failure(CHF).A rapidly growing evidence supports that cardiomyocyte death by apoptosis and necrosis is a primary mechanism for DOX-induced cardiomyopathy.Other types of cell death,such as autophagy and senescence/aging,may participate in this process,too.In this revie... |
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| Keywords: | doxorubicin cardiomyopathy apoptosis necrosis autophagy |
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