阿托伐他汀钙对慢性心功能不全患者心功能及C反应蛋白的影响

目的 研究阿托伐他汀钙对慢性心功能不全患者心功能及C反应蛋白（CRP）的影响.方法 将慢性心功能不全患者64例随机分为治疗组与对照组各32例,对照组予常规限盐、利尿剂及硝酸酯类药物治疗,治疗组在对照组基础上加用阿托伐他汀钙20mg口服,每晚1次,连续治疗60d,60d后检测血清CRP,行心脏彩色多普勒超声检查左室舒张末内径（LVEDd）及左室射血分数（LVEF）的变化.比较2组治疗结果.结果 治疗组及对照组治疗后LVEDd、LVEF、CRP较治疗前比较差异均有统计学意义（P＜0.05）.治疗组改善情况优于对照组,差异有统计学意义（P＜0.05）.结论 阿托伐他汀钙能降低慢性心功能不全患者CRP水平,改善心室重构及心功能,且能够改善患者症状.

Effect of atorvastatin calcium on heart function and C-reaction protein in patients with chronic heart failure

Objective To explore the effect of atorvastatin calcium on heart function and C-reaction protein in pa- tients with chronic heart failure （CHF）. Methods 64 cases of patients with CHF were randomly divided into treatment group and control group ,each of 32 cases. The Control groups were given routine treatment such as salt restriction, diuretics and ni- trates, while the treatment group was added with atorvastatin calcium （20mg oral） for treatment every night. The left ventricular ejection fraction （LVEF） ,left ventricular diastolic dimension （LVEDd） and C-reactive protein （CRP） were checked before and after the treatment in 60 days. The treatment outcome of 2 groups was compared. Results After 60 days treatment, the differences of LVEDd, LVEF, CRP were statistically significant compared with before treatment （ P 〈 0.05 ）. The treatment group was better than the control group in heart function and the level of serum CRP, the difference was significant （ P 〈 0.05 ）. Conclusion The atorvastatin calcium could reduce the level of hs-CRP apparently, improve cardiac function effectively and alleviate clinical symptoms.