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CD44v3和CD44v6在溃疡性结肠炎与其他类型结肠炎中的表达
引用本文:王玉芳,魏兵,欧阳钦. CD44v3和CD44v6在溃疡性结肠炎与其他类型结肠炎中的表达[J]. 临床内科杂志, 2005, 22(5): 303-304
作者姓名:王玉芳  魏兵  欧阳钦
作者单位:610041,成都,四川大学华西医院消化科;610041,成都,四川大学华西医院病理科
摘    要:目的比较CD44v3和CD44v6在溃疡性结肠炎(UC)与对照组(包括感染性结肠炎、阿米巴痢疾、血吸虫性结肠炎及克罗恩病等其他类型结肠炎)中表达的差异.方法免疫组化SP法检测两组患者结肠粘膜CD44v3和CD44v6的表达.结果 UC组患者CD44v3和CD44v6表达阳性率分别为68.8%和56.3%,与对照组比较有显著性增高(P<0.05).UC组与感染性结肠炎、阿米巴痢疾、血吸虫性结肠炎病及克罗恩病分别比较差异仍有显著性(P<0.05).结论 CD44v3和CD44v6的检测有助于鉴别UC和感染性结肠炎等其他类型结肠炎.

关 键 词:溃疡性结肠炎  感染性结肠炎  CD44v3  CD44v6
文章编号:1001-9057(2005)05-0303-02
修稿时间:2004-12-20

The role of the CD44v3 and CD44v6 in the differential diagnosis of ulcerative colitis
Wang Yufang,OUYANG Qin,Wei Bing. The role of the CD44v3 and CD44v6 in the differential diagnosis of ulcerative colitis[J]. Journal of Clinical Internal Medicine, 2005, 22(5): 303-304
Authors:Wang Yufang  OUYANG Qin  Wei Bing
Affiliation:WANG Yufang,OUYANG Qin,WEI Bing.Department of Gastroenterology,West China Hospital,Sichuan University,Chengdu 610041,China
Abstract:Objective To elucidate the differences between ulcerative colitis (UC) and other colitis such as infectious colitis (IC),amebic dysentery and Crohn disease (CD) on expression of CD_ 44v3 and CD_ 44v6.Methods Expressions of CD_ 44v3 and CD_ 44v6 on colonic mucosa were detected by immunohistochemistry (IHC).Results Incidences of CD_ 44v3 and CD_ 44v6 on colonic mucosa were 68.8%, 56.3% in UC patients respectively,they were significantly higher than those in other colitis (P<0.05).Conclusions Detections of CD_ 44v3 and CD_ 44v6 are helpful to differentiate UC from other colitis.
Keywords:Ulcerative colitis  Infectious colitis  CD_ 44v3  CD_ 44v6
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