| CD44v3和CD44v6在溃疡性结肠炎与其他类型结肠炎中的表达 |
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| 引用本文： | 王玉芳,魏兵,欧阳钦.CD44v3和CD44v6在溃疡性结肠炎与其他类型结肠炎中的表达[J].临床内科杂志,2005,22(5):303-304. |
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| 作者姓名： | 王玉芳 魏兵 欧阳钦 |
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| 作者单位： | 610041,成都,四川大学华西医院消化科;610041,成都,四川大学华西医院病理科 |
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| 摘 要： | 目的比较CD44v3和CD44v6在溃疡性结肠炎(UC)与对照组(包括感染性结肠炎、阿米巴痢疾、血吸虫性结肠炎及克罗恩病等其他类型结肠炎)中表达的差异.方法免疫组化SP法检测两组患者结肠粘膜CD44v3和CD44v6的表达.结果 UC组患者CD44v3和CD44v6表达阳性率分别为68.8%和56.3%,与对照组比较有显著性增高(P<0.05).UC组与感染性结肠炎、阿米巴痢疾、血吸虫性结肠炎病及克罗恩病分别比较差异仍有显著性(P<0.05).结论 CD44v3和CD44v6的检测有助于鉴别UC和感染性结肠炎等其他类型结肠炎.
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| 关 键 词： | 溃疡性结肠炎 感染性结肠炎 CD44v3 CD44v6 |
| 文章编号： | 1001-9057(2005)05-0303-02 |
| 修稿时间： | 2004年12月20 |
The role of the CD44v3 and CD44v6 in the differential diagnosis of ulcerative colitis |
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| Wang Yufang,OUYANG Qin,Wei Bing.The role of the CD44v3 and CD44v6 in the differential diagnosis of ulcerative colitis[J].Journal of Clinical Internal Medicine,2005,22(5):303-304. |
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| Authors: | Wang Yufang OUYANG Qin Wei Bing |
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| Institution: | WANG Yufang,OUYANG Qin,WEI Bing.Department of Gastroenterology,West China Hospital,Sichuan University,Chengdu 610041,China |
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| Abstract: | Objective To elucidate the differences between ulcerative colitis (UC) and other colitis such as infectious colitis (IC),amebic dysentery and Crohn disease (CD) on expression of CD_ 44v3 and CD_ 44v6.Methods Expressions of CD_ 44v3 and CD_ 44v6 on colonic mucosa were detected by immunohistochemistry (IHC).Results Incidences of CD_ 44v3 and CD_ 44v6 on colonic mucosa were 68.8%, 56.3% in UC patients respectively,they were significantly higher than those in other colitis (P<0.05).Conclusions Detections of CD_ 44v3 and CD_ 44v6 are helpful to differentiate UC from other colitis. |
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| Keywords: | Ulcerative colitis Infectious colitis CD_ 44v3 CD_ 44v6 |
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