| Abstract: | To test for linkage of the Kells locus to the chromosome trisomic in Down's syndrome, 585 mongoloid and 585 non-mongoloid retardates matched for county of residence were tested. No significant difference in the frequencies of Kell types was detected. The frequency of Kell positives among mongoloids was almost identical to that observed in an independent sample of blood donors drawn from one community in North Carolina. Efforts to detect doasage effects using twofold dilutions of anit-K and anti-k were unsuccessful. Though no evidence for linkage was detected, it is recognized that the possibility of linkage has not been absolutely excluded bt only made less probable. |
