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Elevation of serum prostagladin E levels following electrical stimulation of the midbrain |
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| Authors: | Werner Rosshirt Richard H. Simon Edward G. Shaskan Chester Siok Paula Dore-Duffy |
| Affiliation: | 1. Department of Surgery, Division of Neurosurgery, Neurimmunology, University of Connecticut Health Center, Fermington, CT 06032 U.S.A.;2. Department of Psychiatry Neurimmunology, University of Connecticut Health Center, Fermington, CT 06032 U.S.A.;3. Department of Neurology, Division of Neurimmunology, University of Connecticut Health Center, Fermington, CT 06032 U.S.A. |
| Abstract: | Serum prostaglandin E(PGE) levels were measured in rats immediately following electrical stimulation of the mesencephalic periaqueductal gray (PAG) region and the nucleus raphe magnus (NRM) and compared to controls. An additional group received aspirin prior to PAG stimulation. A significant increase in serum PGE levels was found after stimulation of the PAG, but not the NRM. Aspirin inhibited the stimulation-induced increases in PGE. |
| Keywords: | Endogenous opiates-Periaqueductal gray stimulation-Prostaglandin E |
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