Decreased IgA antibody production in the stomach of gastric adenocarcinoma patients |
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| Authors: | Marianne Quiding-J rbrink, Patrik Sundstr m, Anna Lundgren, Malin Hansson, Malin B ckstr m, Camilla Johansson, Karin Enarsson, Michael Hermansson, Erik Johnsson,Ann-Mari Svennerholm |
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| Affiliation: | aDepartment of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, The Sahlgrenska Academy at University of Gothenburg, Sweden;bDepartment of Medical Chemistry, Institute of Biomedicine, The Sahlgrenska Academy at University of Gothenburg, Sweden;cDepartment of Surgery, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, Sweden |
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| Abstract: | Gastric adenocarcinoma is closely associated with Helicobacter pylori infection. It is also much more frequent in patients with common variable immunodeficiency or selective IgA-deficiency than in the general population. To investigate a possible link between local antibody production and gastric tumors, we studied gastric B cell infiltration and local IgA production in patients with H. pylori induced gastric adenocarcinomas. These studies showed that total and H. pylori-specific IgA antibody levels were substantially lower in gastric tissue from the cancer patients compared to those from asymptomatic H. pylori carriers. However, serum IgA levels were similar in the cancer patients and asymptomatic carriers. As could be expected, H. pylori infected asymptomatic carriers had considerably increased IgA antibody levels compared to uninfected subjects. We conclude that patients suffering from gastric adenocarcinoma have a dramatically decreased local IgA production in the stomach compared to asymptomatic H. pylori infected individuals. |
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| Keywords: | IgA Antibody-secreting cell Gastric mucosa Cancer Human Helicobacter pylori |
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