复苏液体温度对失血性休克兔微循环的影响

目的 :观察输注不同温度液体时失血性休克模型兔微循环变化的特点 ,探讨液体复苏时不同温度液体对改善微循环、提高抗休克疗效的作用。方法 :新西兰雄兔 3 0只 ,随机分为 4组制作休克模型 ,休克模型稳定 3 0min后按相同速度相同液量分别给予低温 ( 10 .7± 1.6℃ )、常温 ( 2 0 .6± 1.3℃ )及温热 ( 3 9.5± 1.3℃ )平衡液和自体血 ;在休克前、休克及液体复苏 1h、2h和 4h监测球结膜微循环血流流态、血管口径、毛细血管数目变化。结果 :⑴各组流态随着液体输注逐渐改善 ,温热组流态恢复明显早于其他两组。⑵温热组在液体复苏 1h、2h和 4h的血管管径均明显大于其他两组 ,组间相比有显著性差异 (P <0 .0 5 )。⑶低温组在液体复苏 1h和 2h血管数目明显减少 ,常温组和温热组血管数目均呈逐步增加趋势。结论 :输注温热液体可加快血流速度 ,扩张局部毛细血管 ,减少血管数目的下降 ,从而改善微循环障碍 ,提高休克后液体复苏的效果

Effects of Fluid Temperature on Hemorrhagic Shock Rabbit Microcirculation

Objective: To observe the change of bulbar conjunctival microcirculation by infusing the different temperature fluids in the rabbit with hemorrhagic shock.Method: After the rabbit hemorrhagic shock model was successfully duplicated, the 30 rabbits were randomized to four groups, receiving hypothermic fluid(10.7±1.6 ℃), normothermic fluid(20.6±1.3 ℃)and hyperthermic fluid(39.5±1.3℃).The velocity of the blood flow, diameter and number of the capillary were measured at baseline, shock and resuscitation phases(1 h,2 h,4 h). Results: ⑴ After resuscitation, the velocity blood flow is recovered in all groups, the hyperthemic group is recovered earlier than other groups. ⑵ The diameter in the hyperthermic group is wider than other groups, and there is the significant difference among groups( P <0.05). ⑶ The number of capillary in the hypothermic group is less than others after resuscitation, but it is increased remarkable in the hyperthemic group.Conclusion: Using hyperthemic fluids can improve the microcirculation and help the resuscitation from shock.