Higher platelet P-selectin in male patients with inflammatory bowel disease compared to healthy males |
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Authors: | Fägerstam J Patrik Whiss Per A |
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Affiliation: | 1. Division of Radiology, Department of Medicine and Care, Faculty of Health Sciences, Link(o)ping University, Link(o)ping, Sweden 2. Division of Pharmacology, Department of Medicine and Care, Faculty of Health Sciences, Link(o)ping University,Link(o)ping, Sweden |
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Abstract: | AIM: To observe if the total amount of platelet P-selectin (tP-selectin) in patients with inflammatory bowel disease (IBD) was related to disease entity or activity, 5-aminosalicylic acid (5-ASA) medication or gender. METHODS: tP-selectin was measured by immunoassay in seventeen IBD patients and twelve healthy controls. RESULTS: Compared to controls, there was no difference of tP-selectin in patients related to disease entity or activity and 5-ASA medication. When the groups were split according to gender the male patient group showed higher levels of tP-selectin compared to male controls (153 ng/mL vs 94 ng/mL, P<0.05). CONCLUSION: Increased tP-selectin levels may alter the inflammatory response and susceptibility to thromboembolic disease. As previously shown with soluble P-selectin, tP-selectin shows gender dependent differences important to consider in future studies. |
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Keywords: | Platelet P-selectin Inflammatory bowel disease 5-aminosalicylic acid Gender |
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