肿瘤血管靶向噬菌体展示肽的研究进展

肿瘤血管表达有正常血管内皮细胞没有或微量表达的蛋白,由于它们具有特征性的结构,故用噬菌体展示技术可以筛选出针对这些蛋白的特异性识别多肽。用此类肿瘤特异性识别多肽如RGD、NGR等作为抗肿瘤药物治疗的靶向分子,将其与药物、纳米颗粒或脂质体等结合起来,由此制备的纳米药物有望明显的抑制肿瘤的生长,并极大程度地减少化疗药物的毒副作用。除此之外,此类多肽还可用于肿瘤血管影像检测等领域的应用。

Advances in the Research of Phage Display Peptides Targeting Tumor Vasculature

Tumor vascular endothelial cells can express some proteins which do not exist or express at a very low level in normal endothelial cells.The phage display peptide libraries can be employed to isolate some specific peptides targeting these proteins because of their distinctive structures.Peptides such as RGD,NGR,isolated by phage display and coupled with drugs and drug carriers such as nanoparticles,liposome,can enhance the efficacy of the therapy while reducing side effects of chemotherapeutics that are associated with traditional therapy.Additionally,such peptides can also be used for imaging and detection of tumor vasculature.