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HLA antigens influence resistance to lung carcinoma |
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| Authors: | Paula J. Romano Mary Bartholomew Philip J. Smith Francine Kloszewski John Stryker John Houck Elliot S. Vessell |
| Affiliation: | a From the Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA b Department of Radiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA c Department of Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA d Department of Pathology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA e Center for Biostatistics and Epidemiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA |
| Abstract: | The concept of genetic factors playing a role in the pathogenesis of lung cancer has gained increased attention. The present study was undertaken to reexamine the question of HLA antigen association with carcinoma of the lung. In a study of 90 patients, a significant association occurred between HLA-DR7 and resistance to lung cancer, after accounting for smoking status and sex. HLA class I antigens were also implicated. These results suggest that major histocompatibility complex loci affect carcinoma of the lung. |
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