The effects of pyridostigmine bromide on progressive ratio performance in male and female rats |
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Authors: | van Haaren F Haworth S C Bennett S M Cody B A |
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Affiliation: | Department of Psychology, University of Florida, Gainesville, FL 32611-2250, USA. haaren@psych.ufl.edu |
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Abstract: | Small doses of pyridostigmine bromide (PB) affect the acquisition and maintenance of food-maintained behavior in laboratory animals. The present experiment was designed to investigate the effects of this drug on food motivation. Male and female rats were trained to respond on a progressive-ratio schedule of reinforcement and treated with different doses of PB. PB dose-dependently decreased breaking points and response rates in male and female rats. Gender differences were not observed. The results indicate that decreased food motivation may be a factor that contributes to the behavioral effects of PB administration. |
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