Identification of a new HLA-DRB1 allele,DRB1*0321 |
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Authors: | Gagne K Bonneville F Cheneau M-L Herry P Pinson M-J Herfray P Cesbron-Gautier A Folléa G Bignon J-D |
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Institution: | Laboratoire d'Immunogénétique et d'Histocompatibilité, EFS Pays de Loire, Nantes cedex, France. |
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Abstract: | This communication reports the identification of a new HLA-DRB1*03 allele identified in three members of a Caucasian French family. This new allele has been officially named HLA-DRB1*0321 by the World Health Organization Nomenclature Committee. The complete exon 2 sequence of DRB1*0321 is identical to that of DRB1*0307 except for the first and second nucleotides of codon 37 (TT replacing AA), which lead to the substitution of a tyrosine for a phenylalanine (AAC-->TTC at position 37). The family study showed that this new allele was transmitted into the HLA-A*0101/09, -B*0801/14, -Cw*0701, -DRB1*0321, -DRB3*0101, -DQB1*0503 and -DPB1*0401 haplotype. The complete exon 2 sequence of this new allele has been previously deposited in the EMBL Sequence Database under accession number AF297266. |
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Keywords: | HLA-DRB1*0321 sequence-based typing |
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