首页 | 本学科首页   官方微博 | 高级检索  
     

鼻咽癌血清NMR代谢组学研究
引用本文:杨洪斌,罗秀,王轶. 鼻咽癌血清NMR代谢组学研究[J]. 现代肿瘤医学, 2012, 20(10): 2042-2044
作者姓名:杨洪斌  罗秀  王轶
作者单位:1. 川北医学院附属医院耳鼻咽喉头颈外科,四川 南充,637000
2. 川北医学院预防医学系,四川 南充,637000
基金项目:四川省卫生厅科研课题(编号:110294)
摘    要:目的:应用核磁共振氢谱和PLS-DA分析方法研究鼻咽癌患者血清的代谢组学变化.方法:临床正常人血清20例和鼻咽癌患者血清20例,采用日本电子600MHz超导核磁共振波谱仪进行检测,并运用PLS-DA分析方法,得出鼻咽癌患者血清代谢组的特征,探讨相关生化过程的改变.结果:鼻咽癌患者和正常人血清的代谢组学具有明显差异.鼻咽癌患者血清中的甲硫氨酸、牛磺酸和胆碱类物质的含量升高,而脂类、异亮氨酸、不饱和脂类、氧化三甲胺和糖类降低.结论:通过上述代谢物的变化可以区分正常人和鼻咽癌患者.这种基于核磁共振氢谱和PLS-DA分析的代谢组学方法可以为鼻咽癌的诊断提供可靠的代谢依据.

关 键 词:鼻咽癌  代谢组学  核磁共振波谱

Serum NMR metabonomics of the nasopharyngeal carcinoma
YANG Hongbin , LUO Xiu , WANG Yi. Serum NMR metabonomics of the nasopharyngeal carcinoma[J]. Journal of Modern Oncology, 2012, 20(10): 2042-2044
Authors:YANG Hongbin    LUO Xiu    WANG Yi
Affiliation:1Department of Otolaryngology Head and Neck Surgery,North Sichuan Medical Colledge Hospital,Sichuan Nantong 637000,China;2Department of Preventive Medicine,North Sichuan Medical Colledge,Sichuan Nanchong 637000,China.
Abstract:Objective:By using 1-H NMR and PLS-DA analysis method to research NPC serum levels’s metabonomics changes.Methods:Select 20 cases clinical normal serum and 20 NPC 20 serum,with the 600 MHz Japanese electronics superconducting magnetic resonance spectroscopy testing instrument and PLS-DA.Results:NPC and normal serum’s metabonomics levels had obvious difference.NPC serum’s methionine,taurine and choline kind material were rised,and lipid,Isoleucine,trimethylamine oxide,sugar and unsaturated lipid reduced.Conclusion:Through the above metabolites changes can distinguish the difference between normal and NPC patients.This kinds of based on 1-H NMR and PLS-DA metabonomics analysis method for the diagnosis of NPC can provide reliable from molecular level.
Keywords:nasopharyngeal carcinoma  metabonomics  1-H NMR spectroscopy
本文献已被 CNKI 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号