Clinical features of second primary cancers arising in early gastric cancer patients after endoscopic resection |
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Authors: | Jung-Wook Kim Jae-Young Jang Young Woon Chang Yong Ho Kim |
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Affiliation: | Jung-Wook Kim, Jae-Young Jang, Young Woon Chang, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul 130-702, South KoreaYong Ho Kim, Department of Surgery, College of Medicine, Kyung Hee University, Seoul 130-702, South Korea |
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Abstract: | AIM: To investigate the incidence and distribution of second primary cancers (SPCs) in early gastric cancer (EGC) patients who underwent endoscopic resection (ER), compared to advanced gastric cancer (AGC) patients who underwent surgery.METHODS: The medical records of 1021 gastric cancer (GC) patients were retrospectively reviewed from January 2006 to December 2010. The characteristics and incidence of SPCs were investigated in those with EGC that underwent curative ER (the EGC group) and those with AGC who underwent curative surgical resection (the AGC group).RESULTS: We ultimately enrolled 184 patients in the EGC group and 229 patients in the AGC group. A total of 38 of the 413 (9.2%) GC patients had SPCs; the rate was identical in both groups. Of these 38 patients, 18 had synchronous and 20 had metachronous cancers. The most common SPC was lung cancer (18.4%), followed by colorectal cancer (13.2%) and esophageal cancer (13.2%). No significant risk factors were identified for the development of SPCs.CONCLUSION: Endoscopists should provide close surveillance and establish follow-up programs to ensure SPC detection in GC patients undergoing curative resection regardless of their clinical characteristics. |
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Keywords: | Second primary cancers Early gastric cancer Endoscopic resection Advanced gastric cancer |
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