| 青蒿酯钠的抗疟机理 |
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| 引用本文： | 蔺福宝,潘华珍.青蒿酯钠的抗疟机理[J].中国医学科学院学报,1989,11(3):180-184. |
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| 作者姓名： | 蔺福宝 潘华珍 |
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| 作者单位： | 中国医学科学院基础医学研究所 北京
(蔺福宝)，中国医学科学院基础医学研究所 北京(潘华珍) |
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| 摘 要： | 青蒿酯钠(sodium artesunate,SA)在碱性条件下可产生超氧阳离子(O_2~-)和过氧化氢(H_2O_2)等活性氧;在pH 7.4条件下虽不能产生活性氧,但可使红细胞中O_2~-和H_2O_2等活性氧的浓度升高,并能增加红细胞膜的脂质过氧化.SA使疟原虫感染红细胞的活性氧增加和膜脂质过氧化程度均比未感染红细胞显著.
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| 关 键 词： | 青蒿酯钠 活性氧 脂质过氧化抗疟机理 |
Peroxidative Antimalaria Mechanism of Sodium Artesunate |
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| Lin Fubao and Pan Huazhen.Peroxidative Antimalaria Mechanism of Sodium Artesunate[J].Acta Academiae Medicinae Sinicae,1989,11(3):180-184. |
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| Authors: | Lin Fubao and Pan Huazhen |
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| Abstract: | Peroxidative antimalaria action of sodium artesunate was studied in vitro. Under alkaline conditions, sodium artesunate could produce active oxygen species, including the superoxide anion (O2) and hydrogen peroxide (H2O2), but no O2 or H2O2 was produced by the drug at pH 7.4. However .sodiumartesunate could increase the concentration of O2 and H2O2 in erythrocytesby increasing membrane lipid peroxidation, with this action being more marked in infected than in normal erythrocytes. |
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| Keywords: | sodium artesunate active oxygen lipid peroxidation antimalaria mechanism |
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