| 亚硒酸钠在小鼠体内对补体活化的抑制作用 |
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| 引用本文： | 侯健存 戴岩. 亚硒酸钠在小鼠体内对补体活化的抑制作用[J]. 中国医学科学院学报, 1989, 11(4): 250-253 |
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| 作者姓名： | 侯健存 戴岩 |
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| 作者单位： | 中国协和医科大学基础部 北京(侯健存，戴岩)，中国协和医科大学基础部 北京(凌允礼) |
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| 摘 要： | 本实验利用火箭免疫电泳(RIE)检测补体C3活化的方法,通过小鼠的体外及体内试验,发现亚硒酸钠(Na_2SeO_3)对小鼠C3在不同活化剂活化的情况下有不同程度的抑制现象。其中对Inulin引起的活化的抑制最为明显,体外和体内实验组与对照组相比均有显著性差异(P<0.05)。而小鼠凝聚IgG引起活化的抑制则弱,实验组与对照组相比无显著性差异(P>0.05)。说明亚硒酸钠对于补体系统活化的旁路途径有一定的抑制作用。
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| 关 键 词： | 补体活化的抑制 亚硒酸钠 |
In Vivo Study of the Inhibitory Effect of Sodium Selenite on Mouse Complement Activation |
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| Hou Jiancun,et al. In Vivo Study of the Inhibitory Effect of Sodium Selenite on Mouse Complement Activation[J]. Acta Academiae Medicinae Sinicae, 1989, 11(4): 250-253 |
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| Authors: | Hou Jiancun et al |
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| Abstract: | A simple and sensitive rocket immunoelectrophoresis technique for the assessment of complement activation was employed to study the effect of sodium selenite on mouse complement activation. It was shown that selenite can ca-use both in vitro and in vivo inhibition of mouse complement activation. The most significant effect was observed in the inulin-activated group; and not in the mouse aggregated IgG activated group. These results suggest that selenite has some inhibiting effect on the alternative complement activation pathway but not on the classical pathway. Therefore, sodium selenite may be applicable in the alleviation or prevention of symptoms of diseases accompanied by alternative pathway complement activation |
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| Keywords: | inhibition of complement activation sodium selenite |
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