| 新维甲类化合物—R—81001对HL—60细胞的分化诱导作用 |
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| 引用本文： | 焦鹭,韩锐.新维甲类化合物—R—81001对HL—60细胞的分化诱导作用[J].中国医学科学院学报,1989,11(2):102-106. |
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| 作者姓名： | 焦鹭 韩锐 |
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| 作者单位： | 中国医学科学院药物研究所 北京
(焦鹭)，中国医学科学院药物研究所 北京(韩锐) |
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| 摘 要： | 应用软琼脂集落形成法选出单克隆HL-60细胞系,系统地研究新维甲类化合物R81001的分化诱导作用。证明该药可使人早幼粒白血病细胞的NBT还原能力明显增强,呈浓度依赖性。形态学观察表明,在药物作用下细胞的核浆比例降低,核仁减少或消失.胞浆中嗜天青颗粒减少,出现特异性颗粒。多数细胞处于中或晚幼粒细胞阶段。非特异酯酶染色试验证明,R81001诱导HL-60细胞沿粒系统定向分化。
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| 关 键 词： | 人早幼粒白血病细胞 细胞分化 维甲类化合物 |
Induction of Differentiation of Human Promyelocytic Leukemia (HL-60) Cells by New Retinoid R-81001 |
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| Jiao Lu,et al.Induction of Differentiation of Human Promyelocytic Leukemia (HL-60) Cells by New Retinoid R-81001[J].Acta Academiae Medicinae Sinicae,1989,11(2):102-106. |
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| Authors: | Jiao Lu |
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| Institution: | Institute of Materia Medica. Beijing |
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| Abstract: | By using soft agar colony-forming assay, a monoclonal subline of human promyelocytic leukemia HL-60 cells was isolated and inducing activity of differentiation of a new retinoid R-81001 on the cells was studied. Ph-enotypic changes, such as biologic behavior, morphological and biochemical characteristics, show that R-81001 can induce HL-60 cells to differentiate along the myloid pathway. |
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| Keywords: | retinoid cell differentiation HL-60 cells |
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