| 人参皂甙Rb1,Rg1对大鼠肝,脑微粒体脂质过氧化的影响 |
| |
| 引用本文： | 黄治森,刘云.人参皂甙Rb1,Rg1对大鼠肝,脑微粒体脂质过氧化的影响[J].中国医学科学院学报,1989,11(6):460-462. |
| |
| 作者姓名： | 黄治森 刘云 |
| |
| 作者单位： | 贵州老年医学研究所，中国医学科学院药物研究所，中国医学科学院药物研究所，中国医学科学院药物研究所 北京，北京，北京 |
| |
| 摘 要： | 人参是一种传统中药,主要有效成分是人参皂甙。为进一步探讨人参的作用机理,作者采用了VitC或Fe~(2 )诱发微粒体脂质过氧化的方法,研究人参皂甙Rb_1、Rg_1对大鼠肝、脑微粒体脂质过氧化的影响,并与Vit E进行比较。材料与方法 实验用Wistar雄性大鼠,体重200～300g,由本院医学动物研究所供给。人参皂甙Rb_1和Rg_1由广州医药工业研究所提供。Vit E为北京市第二制药厂产品。NADPH为Sigma公司产品。Vit C由北京医药采购站供应。L-半胱氨酸为中国科学院生化研究所产品,硫代巴比妥酸(TBA)为北京化工厂产
|
| 关 键 词： | 人参皂甙 微粒体 肝 脑 |
Effect of ginsenosides Rb1 and Rg1 on lipid peroxidation of rat in vitro |
| |
| Y S Huang.Effect of ginsenosides Rb1 and Rg1 on lipid peroxidation of rat in vitro[J].Acta Academiae Medicinae Sinicae,1989,11(6):460-462. |
| |
| Authors: | Y S Huang |
| |
| Abstract: | Ginsenosides Rb1 and Rg1 were found to inhibit to some degree both VitC-NADPH and Fe2(+)-cysteine induced lipid peroxidation of rat liver and brain microsomes. However, the inhibitory effect of Rb1 and Rg1 was obvious in liver microsomes, especially in Vit C-NADPH induced lipid peroxidation of liver microsomes. Besides, Rb1 was shown to be more potent than Rg1 in inhibiting VitC-NADPH or Fe2(+)-cysteine induced lipid peroxidation. The inhibitory effect of Rb1 on VitC-NADPH induced lipid peroxidation was similar to that of VitE at the same concentration. |
| |
| Keywords: | |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
