| 检测人尿诱变性方法的建立：尿诱导人外周血淋巴细胞SCE频率 |
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| 引用本文： | 胡国刚,罗贤懋.检测人尿诱变性方法的建立：尿诱导人外周血淋巴细胞SCE频率[J].中国医学科学院学报,1989,11(4):309-312. |
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| 作者姓名： | 胡国刚 罗贤懋 |
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| 作者单位： | 中国医学科学院肿瘤研究所 北京
(胡国刚，罗贤懋，刘军，刘绣)，中国医学科学院肿瘤研究所 北京(谷梅) |
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| 摘 要： | 随着现代工农业生产的高速度发展。新投入市场的化学合成物及排放到环境中的污染物(包括一些致癌物)日益增多,严重危害人类的健康。为此建立灵敏、快速、可靠的方法对接触环境诱变物/致癌物人群进行检测,已成为环境保护、预防和控制职业性疾病和肿瘤,维护人民身体健康的重要课题。目前已发现
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| 关 键 词： | 尿液检验 尿诱变性 SCE频率 肿瘤 |
A sensitive, simple and economical bioassay for detecting mutagenicity in human urine by determination of SCE frequency in cultured peripheral lymphocytes |
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| G G Hu.A sensitive, simple and economical bioassay for detecting mutagenicity in human urine by determination of SCE frequency in cultured peripheral lymphocytes[J].Acta Academiae Medicinae Sinicae,1989,11(4):309-312. |
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| Authors: | G G Hu |
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| Abstract: | A bioassay was established for detecting mutagenicity in human urine by determination of SCE frequency in cultured human peripheral lymphocytes. The results showed that the SCE frequencies induced by the urine of smokers were significantly higher than those of nonsmokers (P less than 0.01), while SCE frequencies induced by the urine of 20 cancer patients after chemotherapy (19.44/cell) were much higher than those before treatment (9.92/cell, P less than 0.001). Also, higher SCE frequencies were found in all cancer cases after chemotherapy. The authors suggest that this is a more sensitive, reliable, simple, economical and practical assay for detecting mutagenicity of human urine. |
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