| 癌家族成员DNA修复能力,染色体脆性部位及染色体畸变率的比较 |
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| 引用本文： | 吴德丰 傅明. 癌家族成员DNA修复能力,染色体脆性部位及染色体畸变率的比较[J]. 中国医学科学院学报, 1989, 11(6): 423-429 |
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| 作者姓名： | 吴德丰 傅明 |
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| 作者单位： | 中国医学科学院肿瘤研究所 北京(吴德丰，傅明，王秀琴，徐昕，洪婉君)，中国医学科学院肿瘤研究所 北京(吴旻) |
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| 摘 要： | 同时对7个癌家族40名成员的DNA修复能力,染色体畸变率及染色体脆性部位进行分析,结果发现癌家族成员中DNA修复能力低于正常者占80％(32/40),畸变率高于3％者占85％(34/40),染色体脆性部位检出率亦明显增高;DNA修复能力和染色体畸变率均异常者占70％(28/40),表明三项指标在癌家族成员中存在一定的重叠。这种重叠是否增加个体的患癌几率,尚有待长期追随确定.
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| 关 键 词： | 癌家族 DNA修复 染色体脆性部位 染色体畸变率 |
DNA Repair Capacity, Chromosome Aberration Rate and Chromosome Fragile Sites among Members of 7 Cancer Families |
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| Wu Defeng,et al. DNA Repair Capacity, Chromosome Aberration Rate and Chromosome Fragile Sites among Members of 7 Cancer Families[J]. Acta Academiae Medicinae Sinicae, 1989, 11(6): 423-429 |
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| Authors: | Wu Defeng et al |
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| Abstract: | A nucleoid sedimentation technique was developed and used for analysis of DNA repair capacity in 40 members from 7 cancer families. Chromosome aberration rate (CAR) and chromosome fragile sites (CFS) were assayed simultaneously for comparison.It was shown that 32 members (80%) had a decreased DNA repair capacity and 34 (85%) had increased CAR as well as an apparent increase of CFS. 28 members (70%)showed both decreases of DNA repair capacity and increases of CAR. The importance of these criteria in heritable susceptibility to cancer is discussed. |
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| Keywords: | cancer family DNA repair capacity fragile site chromosome aberration rate |
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