Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses |
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Authors: | Ohtani T Ishihara K Atsumi T Nishida K Kaneko Y Miyata T Itoh S Narimatsu M Maeda H Fukada T Itoh M Okano H Hibi M Hirano T |
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Affiliation: | Department of Biology, Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, USA. coyle@mpi.com |
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Abstract: | While CD28 is critical for expansion of naive T cells, recent evidence suggests that the activation of effector T cells is largely independent of CD28/B7. We suggest that ICOS, the third member of the CD28/CTLA-4 family, plays an important role in production of IL-2, IL-4, IL-5, and IFNgamma from recently activated T cells and contributes to T cell-dependent B help in vivo. Inhibition of ICOS attenuates lung mucosal inflammation induced by Th2 but not Th1 effector populations. Our data indicate a critical function for the third member of the CD28 family in T cell-dependent immune responses. |
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