熄风复遂汤联合钙通道抑制剂治疗急性脑梗死近期疗效研究

目的 :观察熄风复遂汤联合钙通道抑制剂治疗急性脑梗死(ACI)的疗效并探讨其作用机制。方法 :选择 75例符合诊断标准的病例 ,7d内起病的ACI病人 ,随机分为治疗组、对照 1组和对照 2组 ,每组 2 5例。治疗组以尼莫地平 10mg( 5 0ml)静脉输注 ,每日 1次 ,同时每日服 1剂熄风复遂汤 ,1个疗程后停用 5d ,继续第 2个疗程。对照 1组 :单用尼莫地平 ,剂量同治疗组。对照 2组 :单服中药。 3组均以 15d为一疗程。结果 :第 1个疗程、第 2个疗程后 ,治疗组与自身治疗前比较 ,NFD有统计学意义 (P <0 .0 5 ,P <0 .0 0 1) ;第 2疗程后 ,治疗组与对照 1组、对照 2组比较 ,NFD均有统计学意义 ;治疗组与对照 1组、对照 2组比较 ,有效率、显效率均有统计学意义 (P <0 .0 5 ,P <0 .0 0 1)。结论 :中药方剂熄风复遂汤联合钙通道抑制剂尼莫地平治疗ACI ,取得比单一用药更好的近期治疗效果 ,且副作用少。

Short- term Effect of Calcium - passage Inhibitor Combined with XFFST for Treatment of Acute Cerebral Infarction (ACI)

Objective: To evaluate the short-term effect and investigate the principle of calcium-passage inhibitor combined with the XFFST of TCM for treatment of acute cerebral infraction (ACI) patients. Methods:The 75 cases of ACI attacked in 7 days were divided in three groups of the treatment group, control group 1 and group 2 randomly, with 25 cases in each group. The treatment groups were given calcium-passage inhibitor (Nimotop) 5 mg (50 ml) in 500 ml NS by IV infusion, combined with XFFST by oral administration once daily, with one therapeutic course of 15 days. The second course was given 5 days later successively; while in the control group 1 and 2, Nimotop and XFFT alone was given respectively with the same dosage and courses. Results: The neural function defects (NFDs) scores after the 1st and 2nd therapeutic course were remarkably improved compared to those of the pre-treatment, which difference was significant (P <0.05 and P <0.001) respectively, while no significant difference of NFDs the treatment group was compared to control group 1 and group 2. Conclusion :By multiple actions for treatment of ACI patients, calcium-passage inhibitor combined with XFFST had better cure for the ACI patients than treatment singleness with, and had less side effect.