三维适形放疗联合多西他赛治疗食管癌的临床观察

目的：观察三维适形放疗联合多西他赛治疗食管癌的临床疗效.方法：选取60例食管癌患者,随机分为实验组30例,对照组30例,实验组实行放疗联合化疗治疗,对照组实行单纯放射治疗.放疗采用6MV-X照射,周-至周五放射治疗,1次/d,总剂量为60～70Gy;化疗给予多西他赛40mg/m2静滴,每周重复,共4～6周.对比观察两组患者的的临床疗效和不良反应.结果：实验组疾病控制率DCR93.3%,对照组80.0%.两组比较有显著性差异（P〈0.05）;两组患者局部症状缓解情况亦有显著性差异（P〈0.05）;两组均无严重不良作用发生.结论：三维适形放疗联合多西他赛治疗食管癌,疗效明显,安全性好,患者易于耐受,生活质量改善明显.

Clinical observation on treating esophageal carcinoma by three dimensionalconformal radiation therapy plus docetaxel

Objective： To observe clinical efficacy of three dimensional conformal radiation therapy plus docetaxel on esophagealcarcinoma. Methods： 90 patients with esophageal carcinoma were randomly divided into the experimental group and the control group, 30cases per group. The experimental group was given chemotherapy plus radiotherapy; the control group was given radiotherapy solo.Radiotherapy used 6MV-X, 1 time per day from Monday to Friday, the total dose was 60~70Gy. 40mg/m2 docetaxel was given inchemotherapy, and repeated for 4~6 weeks. Clinical efficacy and adverse reaction in two groups were observed. Results： DCR inexperimental group was 93.3%, and 80.0% in another group, the difference was statistically significant （P〈0.05）. Local symptoms in twogroups showed significant difference （P〈0.05）. There was no adverse reaction. Conclusion： Three dimensional conformal radiation therapyplus docetaxel showed good clinical efficacy and safety, and improved toleration and life quality.